PGT – Preimplantation Genetic Testing
Preimplantation genetic testing (PGT) is a diagnostic of an embryo in the earliest phases of its development, before implanting it into the uterus.
This step allows us to find embryos with chromosomal abnormalities or hereditary diseases, and transfer only the healthy ones. We can minimalise the risk of pregnancy leading to a disabled child.
Options of Preimplantation Genetic Testing:
PGT-A (preimplantation genetic testing of aneuploidy) to rule out deviations from the normal number of chromosomes
PGT-SR (preimplantation genetic testing of structural rearrangements) to rule out the rearrangements, such as translocation, which was uncovered in one of the parents (exceptionally in both) during the preconception testing
PGT-M (preimplantation genetic testing of monogenic diseases) to rule out hereditary diseases with known genetic cause (both parents being carriers of such a disease, or one of them suffers from it); these include cystic fibrosis, haemophilia, spinal muscular atrophy, muscular dystrophy, etc.
PGT Procedure
We remove a sample of a few cells from the embryos, usually the fifth day after fertilisation. The removed cells are used for genetic analysis. Results allow us to determine which embryos are viable for transfer. Only those without chromosomal deviation or risk of hereditary disease are possible to use for implantation.
