We recommend that couples take a consultation with a clinical genetic before trying to conceive through IVF. This consultation is especially important for couples with a family history of genetic diseases, which threatens to reappear in the following generation. Genetic testing can also uncover whether one of the partners is a carrier – if they have a predisposition to a hereditary disease which did not yet appear in the family, but could in the children of the prospective parent.
How PGT Is Done:
Genetic testing begins with a medical consultation. A clinical genetic discusses the family and personal anamnesis of hereditary diseases in both partners.
Then, a blood sample is taken in order to examine your chromosomes and compose your karyotype (state of all chromosomes in cell nucleus)
Concerning women, we also examine predispositions to heightened blood clotting – thrombophilic mutations (Leiden mutation in gene for factor V and prothrombin mutation in gene for factor II).
In men with a pathological spermiogramme finding, we focus on discovering specific mutation on the level of genes (CFTR gene mutation) and parts of chromosomes (microdeletions of Y chromosome).
Based on our findings, we recommend the most suited treatment and in some cases of IVF, an additional genetic testing of embryo before transferring it to uterus (PGT).