Egg Quality – Adjusting the Stimulation Protocol
One of the key factors we can influence is egg quality. If your first IVF cycle didn’t go as expected, it doesn’t mean you’re out of options. Your body responds differently to hormonal stimulation each time, so trying a new strategy might make all the difference:
- Short antagonist protocol
- Short or long agonist protocol
- Soft stimulation (gentler approach)
Sperm Quality – Can ICSI or MSS Help?
Sperm quality matters just as much as egg quality. Even if fertilization occurred, the embryo’s development can be affected. These advanced techniques can help select the best sperm for fertilization:
- ICSI (Intracytoplasmic Sperm Injection) – The embryologist selects the highest-quality sperm and injects it directly into the egg, increasing the chances of successful fertilization.
- MSS (Microfluidic Sperm Sorting) – A gentle method that filters out damaged sperm and selects the healthiest ones.
Embryo Quality – What If It Wasn’t Optimal?
Not all embryos have the same chances of leading to pregnancy. If implantation failed, these options might help:
- Extended culture– Allows embryologists to select the strongest embryos for transfer.
- PGT (Preimplantation Genetic Testing) – Checks embryos for chromosomal abnormalities. In older women, up to 70% of embryos can be genetically unbalanced, lowering success rates.
Endometrial Quality – Is Everything in Place?
The embryo needs the perfect environment to implant successfully. If the transfer didn’t work, investigating the uterus could provide answers:
- Hysteroscopy – A detailed examination of the uterus to remove polyps, adhesions, or fibroids.
- Endometrial biopsy – Detects possible immune issues or inflammation.
- ERA test – Identifies the ideal timing for embryo transfer.
Luteal Phase Support – Enough Progesterone?
After embryo transfer, progesterone levels play a crucial role in implantation. Studies suggest that a level below 9.2 ng/mL might reduce success rates. A personalized progesterone regimen can make all the difference.
What Now? How to Move Forward?
A failed transfer hurts. It’s completely normal to feel sadness, frustration, or even anger. But remember—every setback provides valuable information for your next attempt.
What can you do right now?
✔️ Talk to your doctor about treatment adjustments.
✔️ Seek emotional support if you need it—you're not alone.
This isn’t the end of your journey. Every step forward brings you closer to your dream.
